个人简介

李玉婧，北京理工大学助理教授（特别副研究员）。2018年获得吉林大学药学专业博士学位，在2016-2018年赴美国哈佛医学院进行科学研究，师从药物递送知名教授Omid C. Farokhzad和Jinjun Shi 教授。2019-2021年在国家纳米科学中心从事博士后研究，合作导师聂广军研究员。多年来从事新型给药系统的设计及研究，在智能纳米药物，微流控合成技术、纳米药物中试放大工艺及纳米药物的临床前体内外评价积累了较多的研究基础，近年来在Nano Letters, Advanced Materials, ACS Nano, Small, Nanomedicine, Bioconjugate Chemistry等杂志发表SCI论文14篇，具有药学、生物学、医学、化学、材料学等多学科的交叉研究背景。

教育/培训经历

2012.9-2018.12，吉林大学，博士（药学）

2008.9-2012.6, 吉林大学，学士（药学）

工作经历

2021.6-至今 北京理工大学，医学技术学院/医工融合研究院

2019.3-2021.5 国家纳米科学中心，博士后

2016.9-2018.9 哈佛医学院，访问学者

学术任职

2020年08月至今，BIO Integration期刊青年编委

2021年07月至今，中国抗癌协会会员

研究领域

天然高分子水凝胶/纳米生物材料的制备、肿瘤基因治疗、免疫治疗、伤口愈合与创面修复、骨再生与骨修复等

讲授课程

《生物医用材料导论》，32学时，春季学期

参与项目

1．中国科学院基础前沿科学研究计划“从 0 到 1”原始创新项目，2019-09-2024-09，200 万元，在研，参与

2．国家自然科学基金委员会,青年基金项目，2016-01至2018-12，21.48万元，已结题，参与

SCI Journal paper

1. Li Yujing#; Ding Jianxun#; Xu Xiaoding#; Shi Rui#; Saw Phei Er; Wang Junqing; Chung Shirley; Li Wenliang; Aljaeid Bader M; Lee Robert J.; Tao Wei; Teng Lesheng*; Farokhzad Omid C.*; Shi Jinjun*; Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy. Nano Letters, 2020, 20 (7), 4857-4863.

2. Li Yujing; Wang Xudong; Zhang Yinlong; Nie Guangjun*; Recent Advances in Nanomaterials with Inherent Optical and Magnetic Properties for Bioimaging and Imaging-Guided Nucleic Acid Therapy. Bioconjugate Chemistry, 2020, 31 (5), 1234-1246.

3. Li Yujing; Lee Robert J.; Huang Xueqin; Li Yuhuan; Lv Bingcong; Wang Tianpeng; Qi Yuhang; Hao Fei; Lu Jiahui; Meng Qingfan; Teng Lirong; Zhou Yulin; Xie Jing*; Teng Lesheng*; Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery. Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13 (2), 371-381.

4. Li Yujing#; Huang Xueqin#; Lee Robert J.; Qi Yuhang; Wang Kaikai; Hao Fei; Zhang Yu; Lu Jiahui; Meng Qingfan; Li Shuai; Xie Jing*; Teng Lesheng*; Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery. Molecules, 2016, 21 (10), 1314.

5. Qu Na#; Sun Yating#; Li Yujing#; Hao Fei; Qiu Pengyu; Teng Lesheng; Xie Jing*; Gao Yin*. Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation. BioMed Eng OnLine, 2019, 18: 11.

6. Xiong Qingqing; Li Yujing; Zhou Kun; Chen Ping; Guo Hua; Chen Lu; Ding Jianxun*; Song Tianqiang*; Shi Jinjun; Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery. Biomaterials Science, 2020, 8 (3), 758-762.

7. Li Yuhuan; Li Yujing; Wang Xinmei; Lee Robert J.; Teng Lesheng*; Fatty acid modified octa-arginine for delivery of siRNA. International Journal of Pharmaceutics, 2015, 495, 527-535.

8. Li Yuhuan; Liu Da; Zhou Yulin; Li Yujing; Xie Jing; Lee Teng Lesheng*; Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer Cells. Journal of Cancer, 2015, 6 (11), 1187-1194.

9. Xu Xiaoding; Saw Phei Er; Tao Wei; Li Yujing; Ji Xiaoyuan; Yu Mikyung; Mahmoudi Morteza; Rasmussen Jonathan; Ayyash Dana; Zhou Yuxiao; Farokhzad Omid C.*; Shi Jinjun*; Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy. Nano Letters, 2017, 17 (7), 4427-4435.

10. Xu Xiaoding#; Saw Phei Er#; Tao Wei; Li Yujing; Ji Xiaoyuan; Bhasin Sushant; Liu Yanlan; Ayyash Dana; Rasmussen Jonathan; Huo Macr; Shi Jinjun*; Farokhzad Omid C.*; ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. Advanced Materials, 2017, 29 (33), 10.1002/adma.201700141.

11. Cheng Keman#; Zhao Ruifang#; Li, Yao; Qi Yingqiu; Wang Yazhou; Zhang Yinlong; Qin Hao; Qin Yuting; Chen Long; Li Chen; Liang Jie; Li Yujing; Xu Jiaqi; Han Xuexiang; Anderson Gregory J.; Shi Jian; Ren Lei; Zhao Xiao*; Nie Guangjun*; Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology. Nature communications, 2021, 12 (1), 2041.

12. Li Yao#; Zhao Ruifang#; Cheng Keman; Zhang Kaiyue; Wang Yazhou; Zhang Yinlong; Li Yujing; Liu Guangna; Xu Junchao; Xu Jiaqi; Anderson Gregory J; Shi Jian; Ren Lei; Zhao Xiao*; Nie Guangjun*; Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition. ACS Nano, 2020.

13. Xu Xiaoding; Wu Jun; Liu Shuaishuai; Saw Phei Er; Tao Wei; Li Yujing; Krygsman Lisa; Yegnasubramanian Srinivasan; Marzo Angelo M De; Shi Jinjun; Bieberich Charles J; Farokhzad Omid C.*; Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small (Weinheim an der Bergstrasse, Germany), 2018, 14 (41), e1802565.

14. Li Yuhuan; Lee Robert J.; Yu Kongtong; Bi Ye; Qi Yuhang; Sun Yating; Li Yujing; Xie Jing*; Teng Lesheng*; Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide. ACS applied materials & interfaces, 2016, 8 (40), 26613-26621.

专利

1. 李剑光，滕乐生，李玉婧，权宇彤，汤海峰，“一种蒽环类药物脂质体注射液的制备工艺”, CN102973509A。

2. 李剑光，滕乐生，李玉婧，郑彬，孟令军, “一种规模化过滤除菌装置”, CN202909632U。

3. 李剑光，滕乐生，李玉婧，孟令军，李金玲，逯家辉，孟庆繁，滕利荣，李玉环，杨爽，郑彬，“一种切向流脂质体挤出装置”，CN202822916U。

4. 李剑光，滕乐生，李玉婧，杨爽，郑彬，刘艳，“一种利用微流聚焦原理生产脂质体的装置”，CN202909112U。

Personal Resume

Dr. Yujing Li, received her B.S. and Ph.D in Pharmacy from Jilin University in 2012 and 2018. From Sep. 2016 to Sep. 2018, Dr. Li got the financial support from Chinese government and Jilin University to work as a visiting Ph.D. student in the Center for Nanomedicine and Department of Anesthesiology at Brigham and Women’s Hospital, Harvard Medical School under the supervision of Prof. Omid C. Farokhzad and Prof. Jinjun Shi. Later, Dr. Li completed her postdoctoral training at National Center for Nanoscience and Technology, UCAS, China under the supervision of Prof. Guangjun Nie. Her primary research interest is in the design and synthesis of functional biomaterials, revealing nano-bio interactions and exploring their different biomedical applications. At this point, She has authored or co-authored 14 academic papers and hold for more than 10 issued/pending patents.

Education Background

2012.09~2018.12, Ph.D., Jilin University

2016.09~2018.09, Joint Ph.D. Student , Harvard Medical School

2008.09~2012.06, B.S., Jilin University

Positions and Employment

2021.06~Present, Assistant Professor, Beijing Institute of Technology

2019.03~2021.05, Postdoc., National Center for Nanoscience and Technology

Professional Membership/Academic Appointments

2021.07~Present, China Anticancer Association, Member

2020.08~Present, Bio Integration, Academic Editors

Research and Teaching Interest

• Bioinspired and biomimetic materials design and synthesis

• Cancer immunotherapy

•Wound healing

•Bone regeneration

•RNA therapeutics